大眼立显眼霜<Melty wink>，能消肿让双眼皮更明显？

今天要说的是这一款眼霜，日本Melty wink大眼立显眼霜，据说可以让双眼皮更加明显、还能消肿 。。。。

听起来很神奇的样子， 于是开始查找资料， 花了很长时间。。。没有找到厂家的信息。。。如果是日本的哪个厂家生产的， 也应该是相当相当不知名了。。

好了， 先来看看用户使用反馈

一.使用反馈

用起來还舒服，效果没那么明显

挺好用的，不知道是不是有增长睫毛的效果，用了以后眼睫毛长了

到手用到今天，已经9天了，没什么卵用，因为是第三方的产品，所以不能确定真假，反正我用着效果一般，应该说没有效果

确实有效果，早上眼睛不肿了

用了两个月了，没看出什么效果，就当眼精华用了。

一直用这款，温和，舒适，抗敏，对抗细纹，补水保湿都是极好的

好用，用了十天，消水肿，黑眼圈也淡了，特别是我生理期那几天眼袋特别肿，再不消眼袋一个月比一个月严重，价钱合理，有效果，还会回购，希望价格再能优惠点就好了，

总是熬夜，用了这款眼睛没肿过，头一次在这家买，希望是正品，以后就他家了。

使用中，还没看到效果

用了很久才来评价，不知道有没有效果，但是精华吸收很快。

消肿效果还不错 别的暂时没感觉到

紧致效果不错，就是滋润差点！干皮的需要再用个眼霜！

比较清透的一款，用完自欺欺人觉得眼皮变薄了，开心～

还好吧，只能说用起来有紧绷的感觉，燃脂效果暂时没看到

用了时候确实是感觉眼皮薄了，也有点吓到..........

用了大概快半个月 感觉没有任何效果

用了一段时间再来评价的。我个人觉得很好推开，不油腻。去浮肿开眼角什么的貌似没有反应，但是黑眼圈确实淡了很多，还是不错哦！

没啥感觉来着，但是眼睛不会肿了是真的

特地用了两天才来评价，已经惊呆了，从来没见过这么有效果的东西，用了两天，早晨起来看镜子，左眼下部的眼袋消下去不少，而且感觉皮肤也紧致了，我是奔着消眼袋来买的，真的好用

Ps： 以上用户使用反馈来自 //p1-tt.byteimg.com/origin/pgc-image/56e6f979d1134e169740b49780f60527.jpg" style="width: 650px;">

Ps： 以上成分来自 http://www.bevol.cn/（该网站成分来自国家食品药品监督管理局，相对可信）

为了方便浏览， 将扣分成分用黄色来表示。

这是一个功效产品， 里面加了很多抗老的功效成分。。。查这些成分的相关文章花了近1天时间。。。写的也相当的痛苦。。。因为没有确切的定论（预警预警，下方大段大段的英文资料堆砌。。）

1. 咖啡因

先看下面的介绍

咖啡因 是神经中枢兴奋药，是有效的促脂解物质，与脂解性激素如神经组织生长因子、迷迭香萃取物、马栗树皮萃取物等配合外用可用于减肥霜。并有紧肤除皱的效果。咖啡因并未被列入化妆品助剂手册，在化妆品中应用的安全性正在研究。[化妆品天然功能成分]

咖啡因对皮肤的安全性如何？ 是否能起到紧肤除皱的效果？ 看下文：

Caffeine is the chief stimulant in beverages such as coffee and tea. It’s often included in skincare products with claims that it will improve the look of cellulite or puffy eyes. Unfortunately, research into caffeine’s effects in this regard are mixed. Caffeine’s popularity in products related to cellulite is due to its distant relationship to aminophylline (an ingredient once thought to improve the look of cellulite), which is a modified form of theophylline, and caffeine contains theophylline.

Applied to skin, caffeine may have soothing and antioxidant properties, especially when skin is exposed to UV light. It can penetrate skin and has a constricting effect, which can help improve the look of redness but also may be sensitizing.

When it comes to puffy eyes, there is no research indicating caffeine can have any benefit; in fact, research has shown caffeine has an inhibitory action on a key protein in skin that helps it look younger. Truly, it’s a mix of pros and cons for skin, though lower amounts (less than 1%) in skincare products probably don’t present much, if any, risk.

References for this information:

Drug Design, Development, and Therapy, October 2014, pages 19,923-1,928

Skin Pharmacology and Physiology, 2013, issue 1, pages 8-14

British Journal of Clinical Pharmacology, August 2009, pages 181-186

The Journal of Clinical and Aesthetic Dermatology, January 2009, pages 36-40

BMC Complementary and Alternative Medicine, March 2006, issue 9, page 17

Bioscience, Biotechnology, and Biochemistry, November 2005, issue 11, pages 2219-2223

Ps： 以上引用来自 http://www.paulaschoice.com/cosmetic-ingredient-dictionary/definition/caffeine

大意是， 咖啡因有抗氧化作用，但并没有确切的证据表明咖啡因能改善眼部浮肿。 在护肤品里的含量一般少于1%， 难以发挥作用， 而一旦超过1%， 可能会产生刺激。

2. 二肽-2

再来看这个成分介绍

二肽-2 在化妆品中作皮肤调理剂、保湿剂、抗氧化剂使用。该成分能改善眼部水肿，是有效的血管紧张素转换酶（ACE）抑制剂，它们可以通过抑制血管紧张素Ｉ转换为血管紧张素II，从而改善血液循环。

难道， 这就是有些人眼部水肿消失的关键成分？ 继续查资料

Mainly works as a skin conditioning agent. Its also believed to improve lymphatic circulation, and for this reason is often used in eye creams aiming to combat dark and puffy under-eye circles. Many cosmtic manufacturers market it as clinically proven to reduce under-eye bagginess and puffiness, however, its difficult to find any published (and unbiased) clinical data supporting such claims.

Ps： 以上引用来自 https://www.truthinaging.com/ingredients/dipeptide-2

大意是，这个成分被许多化妆品厂家用来消除黑眼圈和眼部水肿，但是很难找到任何公布的的、“临床”的数据来支持这种说法。

3. 棕榈酰四肽-3

再来看这个成分介绍

越高棕榈四肽-3 保湿、改善淋巴循环、阻止弹力蛋白流失，多胜肽类成份。

什么叫做改善淋巴循环？ 我们可以把水肿理解为，细胞间隙的组织液过多了， 多的看起来就像肿了一样， 那么， 如果能让组织液更多的进入淋巴和静脉毛细血管， 那么水肿就能缓解或消除。

那么， 这个成分真的能改善淋巴循环吗？ 继续查资料：

Palmitoyl Tetrapeptide-7 is a synthetic peptide comprised of four amino acids that is used in beauty products and cosmetics to suppress the production of excess interleukins,

the chemical messengers which trigger the body’s acute inflammatory response. This can lead to glycation damage, or the process by which glucose links with proteins and causes them to bind together, stiffening tissues. This negatively affects the skins support system, comprised of collagen, elastin and other proteins, and leads to wrinkles, sagging, and uneven skin tone (Source).

Studies have shown that Palmitoyl Tetrapeptide-7 can slow or suppress the production of excess interleukins, therefore inhibiting unnecessary inappropriate inflammatory responses and glycation damage. In vitro, scientists found that Palmitoyl Tetrapeptide-7 induced a marked dose-dependent reduction in interleukin production. The higher the concentration of Palmitoyl Tetrapeptide 7, the greater the reduction in interleukin production – up to 40%. UV radiation is also known to accelerate interleukin production.

Cells exposed to UV radiation and then treated with Palmitoyl Tetrapeptide-7 saw an 86% reduction of interleukin production.

Palmitoyl Tetrapeptide-7 is a key ingredient in Matrixyl 3000 and is used in conjunction with Palmitoyl-Oligopeptide. Together, they can boost the growth of the connective tissues and naturally increasing the production of collagen in the skin; when the production of collagen is increased, the skin can heal and rejuvenate itself.

Ps： 以上引用来自 https://www.truthinaging.com/ingredients/palmitoyl-tetrapeptide-7

注明一下， 这里说的棕榈四肽-7和棕榈四肽-3 是同样一个东西。 引文的大意是： 棕榈四肽-3-可以减缓或抑制生产过量白介素，从而抑制一些炎症反应和糖化损伤。体外试验证实了对白介素的抑制是有效的。

4. 棕榈酰寡肽

再来看这个成分介绍

棕榈酰寡肽 能促进基质蛋白（matrix protein）尤其是胶原蛋白的合成，同时还可能增加弹性蛋白、透明质酸、糖胺聚糖和纤维连接蛋白的生成。该类胜肽通过增加基质细胞活动促进胶原蛋白的合成，使得皮肤看起来更显弹性和年轻。抑制肌肤的茶酚酞和乙酰胆碱过度释放,局部阻断神经传递,使脸部肌肉放松.达到抚细纹的目的。

看上去棕榈酰寡肽是个非常好的抗老成分， 真能达到这个效果吗？ 继续查资料：

Palmitoyl oligopeptide is a blend of several fatty and amino acids that has recently been used in a number of cosmetics and anti-aging creams. This ingredient is being studied for its positive effects on the skin, especially for those who are looking for an anti-aging serum that has the same results as one that uses retinol, but with fewer side effects. While Palmitoyl oligopeptide is still being studied, early tests suggest that this peptide may work to stimulate collagen production and help skin cells remain more stable. This peptide is also known as palmitoyl hexapeptide-12 and Pal-GHK in some skin care circles. While Palmitoyl oligopeptide is currently being used in a number of skin care products, it is important to understand how it may affect different skin types and if there are any side effects associated with its use.

Ps： 以上引用来自 http://www.thedermreview.com/palmitoyl-oligopeptide/

大意是，棕榈酰寡肽对皮肤的作用还在研究当中，早期的一些测试表明能刺激胶原蛋白的生成。。。

5. 乙酰六肽8

再来看这个成分介绍

乙酰六肽8，这也被称为六胜肽，是在皮肤护理用于减少由重复的面部表情带来皱纹外观的肽化合物。是一种生物活性多肽，该成分既可减少已有的面部皱纹，又可有效防止新的皱纹产生。通过抑制神经传导素乙酰胆碱(acetylcholine)的释放，来减少肌肉的收缩，从而达到减少动态纹、表情纹的产生。

这个成分能起到的作用类似肉毒杆菌素， 就是阻断肌肉神经信号的传递， 来达到阻断肌肉收缩，从而缓解表情纹和皱纹。实际效果如何呢？继续查资料：

Commonly referred to as “Botox in a jar” because it’s believed to inhibit the release of neurotransmitters and relax the facial muscles- thus reducing expression lines and wrinkles. Unfortunately, proof of the ingredient’s benefits is scarce. However, one study published in the International Journal of Cosmetic Science did show a 10% concentration of Argireline to reduce wrinkles by 30% over a 30-day period. Youll mostly find this ingredient in skin care products designed to combat the signs of againg, such as anti-aging treatment, facial moisturizer/lotion, concealer, eye cream and foundation.

Safety Measures/Side Effects:

Because Argireline is a recently discovered ingredient within the skincare arena, very little is known regarding is safety and effectiveness. However, it should be noted that,

unlike Botox, which targets specific muscles, Argireline (assuming it works) will relax all muscles of the face. Theoretically speaking, this could also lead to facial sagging because the neurotransmitter release that Argireline inhibits, is also known to maintain facial firmness. Thus, those concerned with facial sagging should approach this ingredient with caution.

Ps： 以上引用来自 https://www.truthinaging.com/ingredients/acetyle-hexapeptide-8

大概意思是： 有一篇报告指出10%浓度的六胜肽能发挥一些减少皱纹的效果。但是， 六胜肽可能会放松所有肌肉，可能会导致皮肤下垂。

6. 乙酰基四肽-5

再来看这个成分介绍

乙酰基四肽-5 温和亲肤，低刺激，小孩和敏感肌肤都可以使用。其味道及刺激性很小。可长期使用，作为保湿剂、调理剂等，应用于个人护理用品领域。具有较好的抗皱能力。

这个成分的保湿性是不错的， 那么是否具有好的抗皱能力呢？ 看资料：

While this ingredient is most often found in eye creams it is also found in shampoo, conditioner, frizz serums, lotions, creams, lip treatments, cleansers, after-sun lotion,

Acetyl tetrapeptisde-5 is a known humectant or hydroscopic moisturizer which helps reduce eye puffiness, improve skin elasticity as well as overall smoothness. This is done by attracting water from deep within in the skin to the outer-most layer of the skin (stratum corneum), taking advantage of this compounds hydroscopic properties (Making Cosmetics). Humectant rich formulas have also been used to treat xerosis (abnormally dry skin) successfully (PubMed). Humectants can also play an important role as emulsifiers within an overall formulation according to the Cosmetics Database.

Ps： 以上引用来自 https://www.truthinaging.com/ingredients/acetyl-tetrapeptide-5

大意是：这个保湿剂有助于减少眼部浮肿，改善皮肤的弹性和光滑的整体。

另外一个资料显示如下：

Acetyl tetrapeptide-5 is a part of this controversy. Found primarily in eye creams, acetyl tetrapeptide-5 has been shown to reduce puffiness and swelling by changing the micro-circulation in the skin in this area, making it less permeable to fluid (Clinics in Dermatology, 2009).

Ps： 以上引用来自 https://www.futurederm.com/spotlight-acetyl-tetrapeptide-5/

大意是： 添加到眼霜里的乙酰四肽-5已经显示，能减少浮肿，并通过改变在该区域中的皮肤微循环肿胀，使得它不易渗透到流体（诊所在皮肤科，2009）。

。。。。。。

好了， 是不是看的很累很累?? 、、、扼。。我在查资料的时候也是很累很累。。中途蒸了3次眼睛。。

从这些资料中， 能看出来：

第1，对于原料生产商来说， 每一个原料， 功效或多或少都被夸大了。。。

第2， 并没有确切的可信的临床证据， 能证明这些原料具有确切的功效。

从用户的使用反馈中， 也能看出来， 有一部分人是感觉到了， 有消肿的作用。。。 注意， 这只对一部分人有了效果。 而对比药物成分， 就能明显的感觉到， 药物的疗效是确定的， 能对所有人有效。。。why？（因为药物成分的疗效是经过大量重复试验、临床测试证明的）

三.总结

日本Melty wink大眼立显眼霜（对一些人有去水肿的效果。改善黑眼圈和眼袋，就不要指望了。 可能会让眼皮变薄(怕怕）

Ps： 本文重点： 抗老成分的功效，为何难以实现？ 如果你去看药物成分的资料， 会发现有翔实的数据、论文、临床资料， 这些确保了药物疗效的精准性。 而化妆品的功效，大多是宣称出来的，没有临床测试，无法令人信服。

写于 2016.12.16 19:23